Journal of Materials Chemistry B

A cascaded amplification carrier-free nanoplatform for synergistic photothermal/ferroptosis therapy via dual antioxidant pathway disruption in cervical cancer

Dual-laser triggered carrier-free self-assembly nano-photosensitizers (Ir-TCF 3 P-FA NPs) with trimodal imaging performance significantly inhibited the progression of human cervical cancer through synergistic photothermal/ferroptosis therapy.

An organotypic model of high-grade serous ovarian cancer to test the anti-metastatic potential of ROR2 targeted Polyion complex nanoparticles

A 3D co-cultured organotypic cancer model to evaluate the anti-metastatic ability of siRNA loaded BSA decorated PICs nanoparticles has been developed.

A triphenylphosphine coordinated cinnamaldehyde-derived copper(i) Fenton-like agent with mitochondrial aggregation damage for chemodynamic therapy

A new CDT agent, Cin-OD-Cu, which could continuously enrich in the mitochondria of A2780 cancer cells for generated ˙OH by Fenton-like reaction and induced mitochondrial damage, cell death.

A RBC membrane-camouflaged biomimetic nanoplatform for enhanced chemo-photothermal therapy of cervical cancer

An RBC membrane-camouflaged biomimetic nanoplatform for enhanced chemo-photothermal therapy of cervical cancer.

Biotinylated and fluorophore-incorporated polymeric mixed micelles for tumor cell-specific turn-on fluorescence imaging of Al3+

We construct tumor-targeting fluorescent mixed nano-micelles for tumor cell-specific turn-on fluorescence imaging of Al3+.

An anti-aggregation NIR-II heptamethine-cyanine dye with a stereo-specific cyanine for imaging-guided photothermal therapy

Polypeptide based nanoparticles of hydrophilic quaternary stereo-specific cyanine (HQS-Cy) have been synthesized, which show efficient NIR-II imaging-guided photothermal therapy for cancer.

A novel surface-enhanced Raman scattering probe based on Au nanoboxes for dynamic monitoring of caspase-3 during cervical cancer cell apoptosis

The highly sensitive and reliable detection, imaging, and monitoring of changes of intracellular caspase-3 are critical for understanding the cell apoptosis and studying the progression of caspase-3-related cervical cancer.

A novel TMTP1-modified theranostic nanoplatform for targeted in vivo NIR-II fluorescence imaging-guided chemotherapy for cervical cancer

A novel IR-783-DOX-TMTP1 theranostic nanoplatform with strong targeting ability was prepared and used for in vivo NIR-II fluorescence imaging of intratumoral vessels and chemotherapy of cervical tumor-bearing mice.

Bioengineered Escherichia coli Nissle 1917 with hematoporphyrin monomethyl ether for targeted sonodynamic therapy and immune activation in ovarian cancer

This bioengineered probiotic platform HW@EcN presents a clinically translatable approach for improving SDT efficacy and immune activation, paving the way for innovative cancer therapies.

Shedding light on photo-redox catalysis of a NIR iridium( iii ) complex for high photocytotoxicity against cisplatin resistant ovarian cancer in 3D tumor spheroids

Here, RM2, through the synergy of a long-lived triplet state and favorable redox potentials, offers NADH oxidation and Type-I/II ROS generation resulting in IC 50 = 60 nM against the cisplatin-resistant ID8 cell line through photo redox catalysis.

A MOF-derived iron oxide nanorod platform for multiplexed detection of ovarian cancer extracellular vesicle biomarkers

MOF-derived superparamagnetic iron oxide nanorods (MOF-IONRs) integrated with mesoporous Au-based SERS nanotags enable rapid, multiplexed EV biomarker detection of ovarian cancer, offering ultrasensitive performance with point-of-care applicability.

A nanoplatform with H 2 O 2 self-supplying capability for synergistic chemo/enzyme dynamic/chemodynamic therapy of ovarian cancer

Schematic illustration of the synthesis of CeO 2 @CPT@CPO and its application for synergistic CDT, EDT, and chemotherapy of tumors.

An artificial intelligence-enhanced early ovarian cancer diagnosis biosensor

A MoS2/PDDA layer-by-layer SERS biosensor enables simultaneous detection of ovarian cancer EVs and multiple membrane proteins, and facilitates diagnostic modeling via machine learning on serum samples.

HD-ALP fluorescent probe: a high-sensitivity tool for alkaline phosphatase imaging and preclinical diagnosis in three ovarian cancer models

A schematic overview of the FL probe HD-ALP designed for dynamic tracking of ALP activity in the different ovarian cells and models.

Biomimetic NIR-II aggregation-induced emission nanoparticles for targeted photothermal therapy of ovarian cancer

An illustration of 2TB-NPs@TM nanocarrier and photothermal therapy targeting ovarian cancer cells. A biomimetic nanocarrier integrating homologous targeting, NIR-II imaging, and photothermal therapy for precise ovarian cancer treatment.

A multistage drug delivery system via 3D-printed personalized TPU scaffold and microfluidic microspheres for nurse-led outpatient treatment of endometrial cancer

Schematic diagram of the multi-level drug delivery system using 3D-printed personalized TPU scaffolds and microfluidic microspheres.

NIR-activated dual-mode oxygen-generating and -delivering nanoplatform for enhanced photodynamic therapy of cervical cancer

NIR-activated IFHFC nanoparticles enable NIR-I/NIR-II imaging and dual oxygenation (CAT-catalyzed O 2 generation and PFH O 2 release), relieving hypoxia and boosting ROS for enhanced PDT.

A single-injection vaccine providing protection against two HPV types

A bivalent single-injection HPV vaccine was designed using a new pulsatile release drug carrier.

Two-phase dual-signal-readout immunosensing platform based on multifunctional carbon nano-onions for ovarian cancer biomarker detection

In order to detect early tumor markers and gain valuable time for treatment, there is an urgent need to develop a fast, cheap, and ultrasensitive multi-reading sensing platform.

Iron nitroprusside as a chemodynamic agent and inducer of ferroptosis for ovarian cancer therapy

A schematic representation of FeNP-induced ROS production and its involvement in ferroptosis.

A co-formulated vaccine of irradiated cancer cells and cowpea mosaic virus improves ovarian cancer rejection

Cowpea mosaic virus adjuvants bind to irradiated cancer cells (ICCs) – the co-delivery of ICCs (the antigen) and CPMV (the adjuvant) demonstrates potent efficacy as a vaccine that protects mice from ovarian tumor challenge.

LHRH conjugated gold nanoparticles assisted efficient ovarian cancer targeting evaluated via spectral photon-counting CT imaging: a proof-of-concept research

Emerging multifunctional nanoparticulate formulations take advantage of nano-meter scale size and surface chemistry to work as a therapeutic delivery agent and a diagnostic tool for non-invasive real-time monitoring using SPCCT imaging technology.

Polymeric engineering of AIEgens for NIR-II fluorescence imaging and detection of abdominal metastases of ovarian cancer in vivo

Polymeric engineering of amphiphilic polymers used for NIR-II AIEgens encapsulation affords high-brightness AIEdots with small size and long blood circulation time, allowing improved fluorescence imaging in vivo.

A new class of teraryl-based AIEgen for highly selective imaging of intracellular lipid droplets and its detection in advanced-stage human cervical cancer tissues

A new class of D–π–A teraryl-based AIEgen 6a was designed and synthesized for selective staining of intracellular lipid droplets.

microRNA-181a silencing by antisense oligonucleotides delivered by virus-like particles

Encapsulation of anti-miR-181a oligonucleotide into plant virus cowpea chlorotic mottle virus (CCMV) improves the stability of both RNA oligonucleotides. Knockdown efficacy was significantly improved with CCMV encapsulation compared to non-encapsulated counterpart.

A sensitive fluorescent probe for β-galactosidase activity detection and application in ovarian tumor imaging

A sensitive fluorescent probe for β-galactosidase activity detection in vivo and near-infrared imaging of ovarian tumors by detecting β-gal.

Photoactivated polyprodrug nanoparticles for effective light-controlled Pt(iv) and siRNA codelivery to achieve synergistic cancer therapy

A photoactivatable polyprodrug nanoparticle system (PPNPsiRNA) was developed for efficient light-controlled codelivery of Pt(iv) and siRNA for synergistic cancer therapy.

Dual ultrasound-activatable nanodroplets for highly-penetrative and efficient ovarian cancer theranostics

Upon US irradiation, FA-H@NDs can be activated for ADV-augmented deep penetration of sonosensitizers and SDT-induced therapy.