NIR-activated dual-mode oxygen-generating and -delivering nanoplatform for enhanced photodynamic therapy of cervical cancer

Biao Dong & Nuernisha Alifu · 2026-03-18

NIR-activated IFHFC nanoparticles enable NIR-I/NIR-II imaging and dual oxygenation (CAT-catalyzed O 2 generation and PFH O 2 release), relieving hypoxia and boosting ROS for enhanced PDT.

Links
DOIPubMed
Journal
Journal of Materials Chemistry B
TL;DR

Combining deep-tissue-penetrating NIR activation with dual-mode oxygenation offers a promising strategy for overcoming key barriers of PDT in solid tumor treatment.

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Institutions
Xinjiang Medical University
Authors
Biao Dong, Nuernisha Alifu
Funding
National Natural Science Foundation of China Grant 52272080National Natural Science Foundation of China Grant 62035011National Natural Science Foundation of China Grant 82202220Science and Technology Department of Xinjiang Uygur Autonomous Region Grant 2023TSYCTD0017Natural Science Foundation of Xinjiang Uygur Autonomous Region Grant Outstanding Youth Project 2023D01E06Natural Science Foundation of Xinjiang Uygur Autonomous Region Grant Youth Top Talent Project 2022TSYCCX0032