Who can access Discovery Lab data?

Discovery Lab data is available to approved research partners. Access requires a research proposal and IRB documentation, reviewed by the OCRA Governance Committee before credentials are issued.

What data is available in Discovery Lab?

Discovery Lab provides de-identified clinical data, patient-reported outcomes from the Living Lab registry, treatment patterns, and linked research datasets contributed by approved institutions.

Is there a cost to access Discovery Lab?

There is no fee for approved academic or nonprofit researchers. Commercial use requires separate licensing. All approved users agree to research-use-only terms before receiving credentials.

How long does the approval process take?

Governance review typically takes 4–6 weeks from complete submission, depending on proposal complexity and IRB status. Status updates are sent by email throughout the review cycle.

Collaboration at the Speed of Inspiration

Discovery Lab

Explore datasets, analytical tools, and collaborative research assets contributed by the global gynecologic cancer community. The Discovery Lab features a growing catalog of resources, with select datasets and workflows accessible through the Discovery Lab Trusted Research Environment (TRE), built for reproducible analysis and collaborative discovery, designed for citizen scientists and professional researchers alike.

As the community grows, so does the platform, expanding through shared data, new contributions, and collaborations that advance gynecologic cancer research worldwide.

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Collaboration at the Speed of Inspiration – Discovery Lab

Explore the Data. Shape What Comes Next.

The Discovery Lab grows with the community. Browse what’s already here, identify additional datasets across the globe, then contribute your own data or suggest a dataset that should be added.

Dataset

A cell atlas of the human fallopian tube throughout the menstrual cycle and menopause

The fallopian tube undergoes extensive molecular changes during the menstrual cycle and menopause. We use single-cell RNA and ATAC sequencing to construct a comprehensive cell atlas of healthy human fallopian tubes during the menstrual cycle and menopause. Our scRNA-seq comparison of 85,107 pre- and 46,111 post-menopausal fallopian tube cells reveals substantial shifts in cell type frequencies, gene expression, transcription factor activity, and cell-to-cell communications during menopause and menstrual cycle. Menstrual cycle dependent hormonal changes regulate distinct molecular states in fallopian tube secretory epithelial cells. Postmenopausal fallopian tubes show high chromatin accessibility in transcription factors associated with aging such as Jun, Fos, and BACH1/2, while hormone receptors were generally downregulated, a small proportion of secretory epithelial cells had high expression of ESR2, IGF1R, and LEPR. While a pre-menopausal secretory epithelial gene cluster is enriched in the immunoreactive molecular subtype, a subset of genes expressed in post-menopausal secretory epithelial cells show enrichment in the mesenchymal molecular type of high-grade serous ovarian cancer.