microRNA-181a silencing by antisense oligonucleotides delivered by virus-like particles

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Nicole F. Steinmetz

doi:10.1039/d2tb02199d

microRNA-181a silencing by antisense oligonucleotides delivered by virus-like particles

Nicole F. Steinmetz · 2023-01-25

Encapsulation of anti-miR-181a oligonucleotide into plant virus cowpea chlorotic mottle virus (CCMV) improves the stability of both RNA oligonucleotides. Knockdown efficacy was significantly improved with CCMV encapsulation compared to non-encapsulated counterpart.

Funding

NCI NIH HHS

R01 CA253615

NIAID NIH HHS

R21 AI161306

National Institutes of Health

R01- CA253615

National Institutes of Health

R21-AI16130

microRNA-181a silencing by antisense oligonucleotides delivered by virus-like particles

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