Shedding light on photo-redox catalysis of a NIR iridium( iii ) complex for high photocytotoxicity against cisplatin resistant ovarian cancer in 3D tumor spheroids

Sumit & Inamur Rahaman Laskar · 2026-02-11

Here, RM2, through the synergy of a long-lived triplet state and favorable redox potentials, offers NADH oxidation and Type-I/II ROS generation resulting in IC 50 = 60 nM against the cisplatin-resistant ID8 cell line through photo redox catalysis.

Links
DOIPubMed
Journal
Journal of Materials Chemistry B
TL;DR

RM2 is established as a multifunctional photosensitizer, in which the synergy of long-lived triplet energy and favorable redox potentials enables diverse photochemical mechanisms, encompassing NADH oxidation and both Type-I and Type-II ROS generation.

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Institutions
Birla Institute Of Technology And Science Pilani
Authors
Sumit, Inamur Rahaman Laskar
Funding
Science and Engineering Research Board Grant CRG/2022/000745/BHSIndian Council of Medical Research Grant 35/9/2020-Nano/BMSDepartment of Biotechnology, Ministry of Science and Technology, India Grant BT/PR33133/MED/32/704/2019