Dalton Transactions

Phenolato Ti(iv) hexacoordinate complexes for anticancer chemotherapy: enhancement of solubility, hydrolytic stability, and cytotoxicity

Five titanium(iv) phenolato complexes were synthesized and fully characterized, and they showed high cytotoxicity, high hydrolytic stability, and enhanced solubility. The halogenated derivatives are identified as the most promising drug candidates.

Unlocking the potential of organopalladium complexes for high-grade serous ovarian cancer therapy

High-Grade Serous Ovarian Cancer (HGSOC) is the most common and lethal subtype of ovarian cancer, known for its high aggressiveness and extensive genomic alterations.

Cytotoxic effects of halogenated tin phosphinoyldithioformate complexes against several cancer cell lines

An organotina compund based on phosphonyl-dithioformate inhibits cancer cell proliferation and induces programmed cell death depending on cell type and shows greater selectivity and potency than cisplatin, affecting DNA in a different way.

Visible light-activatable platinum(iv) prodrugs harnessing CD36 for ovarian cancer therapy

Visible light-activatable Pt(iv) prodrugs harness the upregulated CD36 to facilitate cell entry and killing of drug resistant ovarian cancer cells.

Anticancer ruthenium(ii) tris(pyrazolyl)methane complexes with bioactive co-ligands

New anticancer RuII-tpm complexes are presented, including a synthetic strategy to tether bioactive molecules to the metallic scaffold.

Synthesis, characterization, interactions with the DNA duplex dodecamer d(5′-CGCGAATTCGCG-3′)2and cytotoxicity of binuclear η6-arene-Ru(ii) complexes

Novel binuclear organoruthenium complexes were synthesized and characterized, exhibiting significant DNA affinity and promising cytotoxicity.

Synthesis, chemical characterization, and biological evaluation of a novel auranofin derivative as an anticancer agent

A novel auranofin-inspired compound showed good antiproliferative properties, associated with lower lipophilicity and a faster reactivity, which make this complex have significant pharmaceutical and therapeutic advantages over auranofin itself.

Synthesis and characterization of thiocarbonato-linked platinum(iv) complexes

Novel platinum(iv) complexes with thiocarbonate linkage were synthesized and their cytotoxic activity against ovarian carcinoma cell lines was investigated. Insights into the reaction with ascorbic acid were provided by UHPLC-HRMS.

Adjusting the lipid–water distribution coefficient of iridium(iii) complexes to enhance the cellular penetration and treatment efficacy to antagonize cisplatin resistance in cervical cancer

The effective design of metal complexes to manipulate their lipid–water distribution coefficient is an appealing strategy for improving their cellular penetration and treatment efficacy.

A novel chiral oxazoline copper(ii)-based complex inhibits ovarian cancer growthin vitroandin vivoby regulating VEGF/VEGFR2 downstream signaling pathways and apoptosis factors

An oxazoline-coordinated copper complex regulates the VEGF/VEGFR2 signaling pathway and apoptosis-related factors to resist ovarian cancerin vivoandin vitro.

NMR studies of group 8 metallodrugs:187Os-enriched organo-osmium half-sandwich anticancer complex

Synthesis of this187Os-enriched organo-osmium azopyridine anticancer complex, has allowed determination of187Os NMR J-couplings to ligand1H and13C, and the187Os chemical shift. The complex was also characterised by X-ray crystallography and MS.

Impact of the central atom and halido ligand on the structure, antiproliferative activity and selectivity of half-sandwich Ru(ii) and Ir(iii) complexes with a 1,3,4-thiadiazole-based ligand

Cancer cell selective antiproliferative activity of thiadiazole-based half-sandwich complexes in sensitive and resistant ovarian cancer cell lines is triggered by exchanging Ru for Ir and by switching the halido coligand from chloride to iodide.

Platin-C containing nanoparticles: a recipe for the delivery of curcumin–cisplatin combination chemotherapeutics to mitochondria

We report the synthesis of a curcumin–cisplatin combination chemotherapeutic agent, Platin-C, suitably packaged in a mitochondrion-targeted nanovehicle for enhanced anticancer efficacy and diminished chemotherapy-associated inflammation.

Trinuclear rhenium(i)-based metallocages as anticancer agents towards human cervical cancer cells

In vitro cytotoxicity studies of self-assembled compact trinuclear rhenium(I) based metallocages display anticancer, antimetastatic, antiproliferative and DNA damaging behavior towards human cervical cancer cells comparable to that of cisplatin.

Mixed ligand copper(ii)-diimine complexes of 2-formylpyridine-N4-phenylthiosemicarbazone: diimine co-ligands tune thein vitronanomolar cytotoxicity

The bpy (IC50, 7 nM) and 5,6-dmp (IC50,13.57 nM) Cu(ii) complexes exhibit phenomenal cytotoxicity.

Synthesis and antiproliferative activity of hindered, chiral 1,2-diaminodiamantane platinum(ii) complexes

Platinum-based antineoplastic agents play a major role in the treatment of numerous types of cancer.

Highly cytotoxic gold(i)-phosphane dithiocarbamate complexes trigger an ER stress-dependent immune response in ovarian cancer cells

Highly cytotoxic AuI-dithiocarbamate complexes were designed to induce severe integrative stress in ovarian cancer cells, leading to the surface exposure of calreticulin, which is a first step in the activation of immune system.

Potent and selective anticancer activity of half-sandwich ruthenium and osmium complexes with modified curcuminoid ligands

Synthesis of Ru (ii) and Os(ii) Arene complexes with curcumin-based ligands. Antitumor activity in vitro against A2780 and A2780cis human ovarian carcinoma cell lines. Structure-activity relationships organometallic anticancer complexes.

Comparative NMR metabolomics of the responses of A2780 human ovarian cancer cells to clinically established Pt-based drugs

A systematic and comparative 1H NMR metabolomics study is carried out to analyse the response of A2780 cancer cells to clinically established Pt drugs. The observed changes are referred to specific alterations of cellular processes.

Selenium-containing metallodrug overcomes cervical cancer radioresistance through physical–chemical dual sensitization

Selenium-containing metallodrugs with enzyme-mimicking properties respond to X-ray to achieve radiotherapy sensitization.

Palladium(0) and Juglone: a new alliance in the fight against ovarian cancer

Four Juglone-based Pd(0) complexes with varied ligands were synthesized and characterized. They showed strong cytotoxicity and cancer selectivity. The most promising complex inhibited the PIN1 oncoprotein, as confirmed by Western Blot.