Impact of the central atom and halido ligand on the structure, antiproliferative activity and selectivity of half-sandwich Ru(ii) and Ir(iii) complexes with a 1,3,4-thiadiazole-based ligand

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Radka Křikavová; David Milde; Jan Moncol; Radovan Herchel; Ivan Nemec

doi:10.1039/d3dt01696j

Impact of the central atom and halido ligand on the structure, antiproliferative activity and selectivity of half-sandwich Ru(ii) and Ir(iii) complexes with a 1,3,4-thiadiazole-based ligand

Radka Křikavová & Ivan Nemec et al. · 2023-09-19

6Citations

Cancer cell selective antiproliferative activity of thiadiazole-based half-sandwich complexes in sensitive and resistant ovarian cancer cell lines is triggered by exchanging Ru for Ir and by switching the halido coligand from chloride to iodide.

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Dalton Transactions

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It is possible to emphasize that mainly complex 4 could represent a further step in the development of selective and highly effective anticancer agents, particularly against resistant tumour types.

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Impact of the central atom and halido ligand on the structure, antiproliferative activity and selectivity of half-sandwich Ru(ii) and Ir(iii) complexes with a 1,3,4-thiadiazole-based ligand

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