Ongoing genome doubling shapes evolvability and immunity in ovarian cancer

Andrew McPherson & Sohrab P. Shah et al. · 2025-06-18

Single-cell whole-genome sequencing of 30,260 tumour genomes from 70 samples across 41 patients in the SPECTRUM cohort reveals that ongoing whole-genome doubling drives tumour evolvability and immune evasion in high-grade serous ovarian cancer.
Links
DOIPubMed
Journal
Nature
Institutions
Memorial Sloan Kettering Cancer CenterSun Yat Sen UniversityUniversity Hospital CologneColumbia UniversityUniversity Of British Columbia
Authors
Andrew McPherson, Matthew A. Myers, Duaa H. Al-Rawi, Matthew Zatzman, Adam C. Weiner, Samuel Freeman, Marc J. Williams, Jun Li, Michelle Wu, Seongmin Choi, Roland F. Schwarz, Hunter Green, Emily Ali, Melody DiBona, Nancy Varice, Ritika Kundra, Ying L. Liu, Nicole Rusk, Yulia Lakhman, Simon Tavaré, Samuel Aparicio, Claire F. Friedman, Britta Weigelt, Samuel F. Bakhoum, Sohrab P. Shah
Funding
Investigational Cancer Therapeutics Training Program (ICTTP)The role of chromosomal instability in tumor evolutionQuantifying replication dynamics to predict clonal evolution and drug sensitivity in cancer cells using single-cell whole genome sequencingPathologyMSK SPORE in Genomic Instability in Breast CancerProbing cytosolic nucleic acid sensing pathways in cancerExploiting markers of genomic instability in high-risk pre-invasive ovarian cancerPOTENTIATION OF ANTI-TUMOR IMMUNITY BY ONCOLYTIC VIRUS IN SITU VACCINATION