A Vaccine to Prevent Ovarian Cancer Metastatic Spread

Project summary

Recurrent ovarian cancer that is resistant to chemotherapy is especially difficult to treat. To address this, Dr. Disis developed a vaccine that teaches the immune system to recognize and attack ovarian cancer cells. In animal studies, the vaccine slowed tumor growth, prevented cancer from spreading, and made tumors more sensitive to chemotherapy. Now, Dr. Disis aims to create a stronger anti-cancer immune response specifically in the stomach by testing a new way to deliver the vaccine—on gold beads through the skin. If successful, this research will pave the way to a clinical trial for the vaccine.