Deciphering Spatiotemporal T Cell Clonal Dynamics to Optimize Immunotherapy in Ovarian Cancer

Project summary

This project will explore dynamic changes in the immune cells of ovarian cancer patients receiving immunotherapy, at treatment that kills cancer using the patient’s immune system. Using blood and tumor samples from an immunotherapy clinical trial, we will map the location of individual immune cells within the tumor, and study how they change after treatment by tracking them in the blood. We will also use a new patient-derived live tumor tissue model to study in real-time how these cells respond to treatment. These experiments aim to predict which patients will benefit from treatment and improve how we treat ovarian cancer.