Combining epigenetic therapy and multi-antigen-specific T cells to treat ovarian cancer

Project summary

Ovarian cancer is an aggressive malignancy that has not responded to available immunotherapies. Ovarian cancer is characterized by an immunosuppressive tumor microenvironment and does not have enough T cells to recognize and kill the cancer cells. Our Aims will 1) administer antigen-specific T cells and 2) use epigenetic therapy to transform the tumor microenvironment to cure ovarian cancer.

This grant was made possible in part by generous donations from Ovarian Awareness of Kentucky; Ovarian Cycle Massapequa, in memory of Diane Mahlstadt; Ovarian Fitness Orlando in memory of Kelly, Carol M., Carol T., Adi, Rose, Judi, Vicky, Terry, Wendy, Adriana, Sherry P., all our Teal Divas and ToTEALly Sisters; and Ovarian Cycle Tampa, in loving memory of Franci Golman Rudolph and Suzanne Maloney.