Enhancing Anti-tumor Response Through Regulation of Cancer-associated Fibroblasts in Ovarian Cancer

Project summary

Our work focuses on a cell type referred to as cancer-associated fibroblasts that are found in ovarian cancer tumors. Specifically, we will study how cancer-associated fibroblasts that carry the DDR2 protein can affect how ovarian cancer cells respond to anti-cancer drugs and immune cells. Our research will provide insight into countering drug resistance, and into identifying drugs that promote an anti-cancer immune response.