Targeting Cancer Stem Cell Vulnerability in Ovarian Cancer

Project summary

This project will explore how a specific RNA molecule, called XIST, affects the behavior of ovarian cancer stem cells that drive tumor growth and resistance to treatment. The research will test whether blocking a key energy process in these cells can stop them from spreading. Using patient-derived tumor models, the goal is to find better ways to identify aggressive tumors and match them with targeted treatments. This work aims to improve outcomes for people with ovarian cancer by developing personalized therapy based on tumor characteristics.