Investigating the Role of Chromosomal Instability in Ovarian Cancer Initiation

Project summary

We are studying the earliest events in ovarian cancer development in the fallopian tubes. By examining the pre-tumor ecosystem in patient tissues and using a specialized mouse model, we aim to define the transitions from pre-cancer to invasive ovarian cancer. Our goal is to find features that predict which patients are at higher risk and may benefit from early treatment and to better understand the origins of ovarian cancer.

This grant was made possible by a generous donation from Paul O’Keefe in memory of Linda O’Keefe