Targeting SPP1 in the TME as a therapeutic strategy to chemosensitize ovarian tumors

Project summary

High-grade serous tubo-ovarian cancer (HGSC) is the most prevalent form of ovarian cancers, a majority of which are chemo resistant. The tumor microenvironment (TME) plays an important role in modulating chemo resistance. Osteopontin (OPN) or SPP1 found in the TME is elevated in aggressive tumors. Here we aim to target OPN and understand its effect in sensitizing ovarian tumors to chemotherapy. We also aim to mechanistically dissect the transcriptional program modulated by OPN using a multiomic approach. Ultimately we want to develop OPN as an attractive target in the TME that can improve response to therapy and increase survival.

This grant was made possible by a generous donation from The Juliet Viola Kniffen Foundation in memory of Elizabeth Ann Maggio.