Decoding the Early Immune and Genomic Alterations Driving HGSC Initiation

Project summary

This project aims to uncover the earliest warning signs of ovarian cancer by tracking immune changes and DNA damage in the fallopian tubes before cancer forms. Using advanced AI-driven analysis of spatial proteomic and transcriptomic data, we will study tissue samples from the earliest signs of abnormality through to late-stage cancer. By identifying patterns that predict which early lesions may become cancerous, this research could lead to earlier detection, when treatment is most effective, and help guide prevention strategies for those at highest risk.

This grant was made possible by a generous donation from The Edmée Firth Fund for Research in Ovarian Cancer (EFFROC).