Aldehyde dehydrogenase inhibitors promote DNA damage in ovarian cancer and synergize with ATM/ATR inhibitors

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doi:10.7150/thno.51885

Aldehyde dehydrogenase inhibitors promote DNA damage in ovarian cancer and synergize with ATM/ATR inhibitors

Edward Grimley & Ronald J. Buckanovich et al. · 2021-01-20

Links

DOI PubMed

Journal

Theranostics

Authors

Edward Grimley, Alexander J. Cole, Thong T. Luong, Stacy C. McGonigal, Sarah Sinno, Dongli Yang, Kara A. Bernstein, Ronald J. Buckanovich

Funding

Isozyme-selective ALDH Inhibitors for Sensitizing Ovarian Cancer Stem-like Cells to Chemotherapy ALDH Inhibition as Modulator of Tumor Immunobiology Replication fork dynamics and repair by Rad51 paralogs after DNA alkylation RAD51 paralog function in cancer predisposition and genome integrity

NCI NIH HHS

R01 CA214567

NCI NIH HHS

R01 CA238315

NIEHS NIH HHS

R01 ES030335

NIEHS NIH HHS

R01 ES031796