NNMT inhibition in cancer-associated fibroblasts restores antitumour immunity

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Janna Heide; Samarjit Patnaik; Maria Francesca Allega; Kaiting Yang; Ethan Teich; Qiaoshan Lin; Hardik Shah; Lisa Schweizer; Andre White; Sayedabdulrazzaq A. Alhunayan; Hua Liang; Matthias Mann; Gordon M. Stott; Matthew D. Hall; Ralph R. Weichselbaum; András Piffkó; Ernst Lengyel

doi:10.1038/s41586-025-09303-5

NNMT inhibition in cancer-associated fibroblasts restores antitumour immunity

Janna Heide & Ernst Lengyel et al. · 2025-07-23

Cancer-associated fibroblasts (CAFs) have a pivotal cancer-supportive role, yet CAF-targeted therapies are lacking

NNMT inhibition in cancer-associated fibroblasts restores antitumour immunity

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