Matthew D. Hall

NNMT inhibition in cancer-associated fibroblasts restores antitumour immunity

Tumors are surrounded by supportive cells called cancer-associated fibroblasts (CAFs), which normally help protect the tumor from the immune system. The researchers found that an enzyme in these fibroblasts, called NNMT, is a key driver of this protection: it triggers the release of immune-suppressing molecules that recruit "suppressor" immune cells to shield the tumor from attack, particularly in high-grade serous ovarian cancer, the most common and deadly form of ovarian cancer.