Investigator
Metabolomics platform Director · University of Chicago Medicine Comprehensive Cancer Center, Comprehensive Cancer Center
NNMT inhibition in cancer-associated fibroblasts restores antitumour immunity
Tumors are surrounded by supportive cells called cancer-associated fibroblasts (CAFs), which normally help protect the tumor from the immune system. The researchers found that an enzyme in these fibroblasts, called NNMT, is a key driver of this protection: it triggers the release of immune-suppressing molecules that recruit "suppressor" immune cells to shield the tumor from attack, particularly in high-grade serous ovarian cancer, the most common and deadly form of ovarian cancer.
Metabolomics platform Director
University of Chicago Medicine Comprehensive Cancer Center · Comprehensive Cancer Center
Researcher
Massachusetts General Hospital
Research Assistant
Memorial Sloan Kettering Cancer Center · Cell Metabolism Core Facility
Associate
Albert Einstein College of Medicine, Yeshiva University · Stable Isotope and Metabolomics Core Facility
Analytical Chemist
Procter and Gamble Co · Trace Analytical Core
Clinical Research Associate
Sun Pharma (India) · Bioequivalance
Master of Science
Fairleigh Dickinson University · Chemistry
Bachelor of Pharmacy
Sant Gadge Baba Amravati University
