Functional evaluation and clinical classification of BRCA2 variants

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Huaizhi Huang; Chunling Hu; Jie Na; Steven N. Hart; Mohamed Abozaid; Paulo Cilas Morais Lyra; Katherine L. Nathanson; Susan M Domchek; Mark E. Robson; Miika Mehine; Chaitanya Bandlamudi; Diana L. Mandelker; Alvaro N Monteiro; Wenan Chen; Marcy Richardson; Fergus J. Couch

doi:10.1038/s41586-024-08388-8

Functional evaluation and clinical classification of BRCA2 variants

Huaizhi Huang & Fergus J. Couch et al. · 2025-01-08

Germline BRCA2 loss-of function variants, which can be identified through clinical genetic testing, predispose to several cancers

Funding

NCI NIH HHS

R01 CA225662

NCI NIH HHS

K12 CA090628

NCI NIH HHS

P30 CA008748

NCI NIH HHS

P50 CA116201

NCI NIH HHS

R35 CA253187

Functional evaluation and clinical classification of BRCA2 variants

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