Arf6-mediated macropinocytosis-enhanced suicide gene therapy of C16TAB-condensed Tat/pDNA nanoparticles in ovarian cancer

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doi:10.1039/d1nr03974a

Arf6-mediated macropinocytosis-enhanced suicide gene therapy of C16TAB-condensed Tat/pDNA nanoparticles in ovarian cancer

· 2021-09-02

12Citations

2Influential

The cellular uptake of C16TAB-condensed Tat/pDNA nanoparticles (Tat/pDNA/C16TAB, T–P–C) was controlled by Arf6-dependent, Rab-activated macropinocytosis, which promoted T–P–C nanoparticle-based suicide gene therapy of ovarian cancer.

Links

DOI PubMed

Journal

Nanoscale

TL;DR

These C16TAB-condensed Tat/pDNA nanoparticles combined with the dual molecular imaging strategy provides a novel intracellular delivery platform for high-efficient, precise suicide gene therapy of ovarian cancer.

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Funding

Chinese Pharmaceutical Association-Yiling Pharmaceutical Innovation Fund Grant CPAYLJ202003 Nankai University Grant NCC2020PY20