Nanoscale

Zwitterionic nanoparticles for thermally activated drug delivery in hyperthermia cancer treatment

Through RAFT emulsion polymerization, zwitterionic nanoparticles (NPs) were synthesized as thermally activated drug release systems. Following hyperthermia, drug-loaded NPs outperforms the therapeutic effect of the free drug in ovarian cancer cells.

Study of the biomolecular corona of surface-modified polystyrene and silica nanoparticles: application to cancer

Surface-tailored nanoparticles capture distinct biomolecular corona patterns, enabling proof-of-concept identification of cancer-specific molecular signatures.

Emerging SERS and TERS MoS2 platforms for the characterization of plasma-derived extracellular vesicles

2D-MoS2 flakes as SERS and TERS platforms for the characterization of extracellular vesicles derived from blood plasma for ovarian cancer detection (Developed using CorelDRAW).

Local mucosal immunization of self-assembled nanofibers elicits robust antitumor effects in an orthotopic model of mouse genital tumors

In this study, we proposed that local mucosal immunization of nanofibers via the intravaginal route represented a promising vaccination strategy for the treatment of genital tumor lesions such as cervical cancer.

Low-dose exposure to phytosynthesized gold nanoparticles combined with glutamine deprivation enhances cell death in the cancer cell line HeLa via oxidative stress-mediated mitochondrial dysfunction and G0/G1 cell cycle arrest

Glutamine deprivation sensitizes cancer cells HeLa to mitochondrial inactivity and cell cycle arrest mediated cell death induction by low-dose phytosynthesized gold nanoparticles.

An integrated microfluidic electrochemical assay for cervical cancer detection at point-of-care testing

IMEAC is an integrated microfluidic electrochemical assay for cervical cancer detection at point of-care testing.

Spherical petal-like ZnO–NiO p–n junction as an excellent ROS scavenger to inhibit the proliferation and migration of ovarian cancer cells

ROS promote ovarian cancer progression. One-step hydrothermal ZnO–NiO p–n junction enhances ROS adsorption, inhibits A2780/SKOV3 cells in vitro / vivo , scavenges ROS, is safe for KGN cells, a new ovarian cancer nanotherapy.

Near-infrared imaging of intraperitoneal ovarian cancer enhanced by BrCy112 in a dual mode (MR and NIR), dual-Gd nanoparticle

Dual-Mode-Dual-Gd (DMDG) nanoparticles incorporating BrCy112 or ICG.

Comparative evaluation of polymer coated versus antibody modified SPIONs for tumor detection using magnetic particle imaging

This study reveals how surface modifications of SPIONs impact their properties, enhancing MPI's potential for tumor imaging.

Engineering macrophage membrane-camouflaged nanoplatforms with enhanced macrophage function for mediating sonodynamic therapy of ovarian cancer

To overcome the immunosuppressive tumor microenvironment of ovarian cancer, we constructed a nanoplatform that combines sonodynamic therapy with immunotherapy.

Recent advances in biotin-based therapeutic agents for cancer therapy

Biotin binds to drugs in two main modes: SMBCs and NBCs. Tumor cells have more biotin receptors than normal cells, allowing for greater biotin uptake, which can enhance drug delivery to tumors.

Cleavable energy transfer labeled oligonucleotide probe for enhanced isothermal amplification detection and nano digital chip-based readout

We present a novel energy transfer-labeled oligonucleotide probe designed to enhance the sensitivity and specificity of LAMP assay for HPV 16 detection. Our approach achieves a detection limit of 1 fM and spans a dynamic range of five orders of magnitude.

Human spermbots for patient-representative 3D ovarian cancer cell treatment

Human-sperm driven micromotors are attractive for locally delivering high concentrations of drug in hard-to-reach disease sites such as cervical cancer and early ovarian cancer lesions by non-invasive means.

Transforming a highly toxic agent DM1 into injectable safe nanomedicines via prodrug self-assembly for the treatment of taxane-resistant cancer

Through a PUFA strategy, highly toxic DM1 was transformed into a safe self-assemble nanoprodrug, which had low systemic toxicity and could be used to treat taxane-resistant cervical cancer.

Arf6-mediated macropinocytosis-enhanced suicide gene therapy of C16TAB-condensed Tat/pDNA nanoparticles in ovarian cancer

The cellular uptake of C16TAB-condensed Tat/pDNA nanoparticles (Tat/pDNA/C16TAB, T–P–C) was controlled by Arf6-dependent, Rab-activated macropinocytosis, which promoted T–P–C nanoparticle-based suicide gene therapy of ovarian cancer.

An ovarian spheroid based tumor model that represents vascularized tumors and enables the investigation of nanomedicine therapeutics

3D tumors created by simple subcutaneous spheroid injection represents a robust and more vascular murine tumor model and can be a relevant platform to test anti-cancer therapy.