Journal

Journal of Clinical Ultrasound

Papers (35)

Comparison of the Diagnostic Performance of Ovarian Adnexal Reporting Data System (O‐RADS) With IOTA Simple Rules and ADNEX Model for Classifying Adnexal Masses: A Head‐To‐Head Meta‐Analysis

ABSTRACTObjectiveTo compare the diagnostic accuracy of O‐RADS (Ovarian Reporting and Data System) and IOTA (international Ovarian Tumor Analysis group) simple rules (SR) and ADNEX (Assessment of Different NEoplasias in the adnexa) model for discriminating benign from malignant adnexal masses using meta‐analysis.MethodsA systematic search of studies comparing O‐RADS with SR and/or ADNEX in the same set of patients with an adnexal mass was performed in Medline, Web of Science, and Scopus databases from January 2020 to September 2023. Quality was assessed using the QUADAS‐2 tool. Quantitative meta‐analysis was performed.ResultsNine articles comprising 3924 women (3979 adnexal masses) were ultimately included after exclusions. Three studies compared O‐RADS versus SR, three studies compared O‐RADS versus ADNEX, and three studies compared all three methods. The risk of bias was high for patient selection in QUADAS‐2 in all studies. Six studies compared O‐RADS versus SR; no significant differences were found (pooled sensitivity and specificity of O‐RADS and IOTA SR were 94.0% and 77.0%, and 91.0% and 87.0%, respectively. p = 0.2204). Six studies compared O‐RADS versus ADNEX; no significant differences were found (pooled sensitivity and specificity of O‐RADS classification system and ADNEX were 95.0% and 79.0%, and 91.0% and 88.0%, respectively. p = 0.2307).ConclusionO‐RADS classification has a similar diagnostic performance to IOTA SR and ADNEX for discriminating benign and malignant adnexal masses.

Preliminary Study on the Value of Contrast‐Enhanced Ultrasound in Enhancing Early Vascular Architecture for the Differential Diagnosis of Benign and Malignant Endometrial Lesions

ABSTRACT Objective To investigate the diagnostic value of contrast‐enhanced ultrasound (CEUS) in differentiating benign and malignant endometrial diseases by analyzing the early arterial vascular architecture on CEUS images. Methods A prospective study was conducted at the Sichuan Integrative Medicine Hospital to enroll 70 suspected endometrial lesion patients with a mean age of 42.5 ± 8.2 years (range 27–69 years). The patients underwent conventional ultrasound and CEUS examinations, and pathological examinations were obtained through surgery or curettage. They were divided into the benign group and malignant group according to their pathological types. The CEUS image features were analyzed, and the sensitivity, specificity, positive predictive value, and other parameters were compared between the two groups by carefully observing the early enhancement images and comparing the differences in the vascular architecture, including the shape of the vessels, the number of vessels, and the vessel diameter. Results There were significant differences in vascular shape, number, and diameter between the two groups. The difference in vascular morphology was highly statistically significant ( p  < 0.001). The “vascular supply” was used for the diagnosis of malignant diseases of the endometrium with a high sensitivity of 95.8%, specificity of 77.5%, positive predictive value of 71.8%, and accuracy of 84.4%. When the maximum inner diameter exceeded 1.5 mm, the sensitivity and specificity for the diagnosis of malignant lesions were 95.8% and 82.5%, respectively, with a positive predictive value of 76.6% and an accuracy of 87.5%. When the average inner diameter exceeded 1.22 mm, the sensitivity for the diagnosis of malignant endometrial lesions was 87.5%, the specificity was 80%, and the accuracy was 82.8%. Conclusions The utilization of CEUS vascular architecture holds significant clinical value in the diagnosis of both benign and malignant endometrial diseases, thereby warranting further comprehensive investigation.

Transvaginal ultrasound versus magnetic resonance imaging for preoperative assessment of myometrial infiltration in patients with low‐grade endometrioid endometrial cancer: A systematic review and head‐to‐head meta‐analysis

AbstractPurposeWe aimed to compare the diagnostic performance of magnetic resonance imaging (MRI) and transvaginal ultrasound (TVS) for detecting myometrial invasion (MI) in patients with low‐grade endometrioid endometrial carcinoma.MethodsA comprehensive search of MEDLINE (Pubmed), Web of Science, Embase and Scopus (from January 1990 to December 2022) was performed for articles comparing TVS and MRI in the evaluation of myometrial infiltration in low‐grade (grade 1 or 2) endometrioid endometrial carcinoma in the same group of patients. We used QUADAS‐2 tool for assessing the risk of bias of studies.ResultsWe found 104 citations in our extensive research. Four articles were ultimately included in the meta‐analysis, after excluding 100 reports. All articles were considered low risk of bias in most of the domains assessed in QUADAS‐2. We observed that pooled sensitivity and specificity for detecting deep MI were 65% (95% confidence interval [CI] = 54%–75%) and 85% (95% CI = 79%–89%) for MRI, and 71% (95% CI = 63%–78%) and 76% (95% CI = 67%–83%) for TVS, respectively. No statistical differences were found between both imaging techniques (p > 0.05). We observed low heterogeneity for sensitivity and high for specificity regarding TVS; and moderate for both sensitivity and specificity in case of MRI.ConclusionsThe diagnostic performance of TVS and MRI for the evaluation of deep MI in women with low‐grade endometrioid endometrial cancer is similar. However, further research is needed as the number of studies is scanty.

Assessing the Clinical Characteristics and the Role of Imaging Modalities in Uterine Sarcoma: A Single‐Center Retrospective Study From Vietnam

ABSTRACTBackgroundThis study aims to describe the clinical and imaging characteristics of uterine sarcomas and the role of imaging modalities in assessing them.Materials and MethodsThis retrospective study enrolled all patients diagnosed with uterine sarcoma at Tu Du Hospital, Vietnam between January 2020 and December 2023. The findings of ultrasound (US) and magnetic resonance imaging (MRI) were compared to histology as the reference.ResultsAmong 78 patients, 46.2% of cases were menopause. Abnormal vaginal bleeding was the most common symptom. Three common types of uterine sarcoma were leiomyosarcoma (50.0%), low‐grade endometrial stromal sarcoma (23.1%), and carcinosarcoma (19.2%). Some imaging features of uterine sarcomas were found including nontypical lesion of fibroid (89.7%), solitary mass (84.6%), inhomogeneous structure (76.9%), invisible endometrium (67.9%), moderate‐rich vascularization on Doppler signal (57.7%), irregular border of tumor (48.7%), classification of FIGO 0 (44.9%), cystic area within tumor (42.3%), acoustic shadowing (34.6%), “cooked” appearance (9.0%), and calcification image in tumor (6.4%). The sensitivity of standard US, consultant US, and MRI was 56.4%, 88.4%, and 87.5%, respectively.ConclusionsBesides clinical presentations, uterine sarcomas present some specific features on US. Consultant US and MRI could be added to standard US to increase the accuracy and help in surgical decision making where applicable.

Elastographic and vascular findings of uterine myomas assessed by ultrasound

AbstractObjectiveThe objectives of this study were to evaluate the vascularization pattern of uterine myoma (UM) by ultrasonography using Superb Microvascular Imaging (SMI) and tissue stiffness elastography.MethodA prospective and cross‐sectional study was carried out between March 2020 and December 2022 among women with clinical and ultrasound diagnosis of UM who would subsequently undergo radiofrequency ablation. Ultrasound examination was performed using both transvaginal and transabdominal routes. UM vascularization pattern was assessed by power Doppler (PD) and SMI, while elastographic pattern was assessed by shear wave (SWE) and strain (STE). FIGO classification, location, and measurement of the largest UM were also described.ResultsA total of 21 women diagnosed with UM were evaluated. There was a predominance of nulliparous women and 20 women (95.2%) reported desire for pregnancy. Of the 18 women with abnormal uterine bleeding, 15 (83.3%) had abdominal cramping. As far as previous treatment, 7 (33.3%) had undergone myomectomy for other UM. The mean uterine and UM volumes were 341.9 cm3 (90–730) and 126.52 cm3 (6.0–430), respectively. There was a predominance of hypoechogenic lesions (90.5%). There was also preponderance of UM in the FIGO 2–5 classification (n = 9; 42.9%). Vascularization patter was mostly moderate (score 2) in 9 cases (42.9%). The majority of UM were considered to have intermediate stiffness (n = 10; 47.6%).ConclusionThe majority of UM showed vascularization and moderate stiffness. A relationship was observed between the stiffness of the UM assessed by elastography and its FIGO classification.

Differences in Imaging Findings Between Benign and Borderline Ovarian Serous/Mucous Tumors

ABSTRACT Objectives To retrospectively analyze the differences in imaging findings between benign and borderline ovarian serous/mucous tumors. Methods Imaging features of benign and borderline ovarian tumors were analyzed, including the tumor maximum diameter, laterality, tumor morphology, proportion of solid components, and the number of papillary processes in cystic solid tumors. Results A total of 189 tumors were evaluated, including 117 benign tumors and 72 borderline tumors. The mean maximum diameter of borderline tumors was higher than that of benign tumors (14.32 ± 9.93 vs. 8.62 ± 6.69 , p  < 0.05). Borderline tumors with solid components accounted for more than benign tumors (41.67% vs. 8.55%). The proportion of solid component volume/tumor volume > 15% in both benign and borderline tumors was very small (1.71%, 4.71%). In unilocular cysts and multilocular cysts, borderline tumors with diameters > 10 cm accounted for more than benign tumors. The sensitivity and specificity in distinguishing benign and borderline tumors of ultrasonography O‐RADS are slightly lower than those of SR of IOTA (86.1% vs. 91.7%, 81.2% vs. 82.1%). Conclusions In conclusion, the borderline tumors are larger and have more solid components than the benign tumors. The sensitivity and specificity in distinguishing benign and borderline tumors of ultrasonography O‐RADS are slightly lower than those of SR of IOTA.

Correlation between preoperative imaging biomarkers and histological prognostic factors in endometrial cancer: A prospective study

AbstractPurposeWe compared transvaginal ultrasound (TVUS) and magnetic resonance imaging (MRI) for detecting myometrial infiltration, cervical involvement, and for measuring tumor volume in endometrial cancer patients. We also correlated tumor volume to worse histological prognostic factors.MethodsWe recruited women with a histological diagnosis of endometrial cancer between March 2019 and March 2021. Inclusion criteria were: age ≥ 18 years, written informed consent, biopsy‐proven endometrial cancer, absence of previous neoadjuvant chemo‐ or radiotherapy treatment, patient suitable for primary surgery. Exclusion criteria were: advanced disease stage and other coexisting malignant tumors. TVUS and MRI were used, in the absence of any contraindication. We compared the preoperative imaging results with final histopathology.ResultsThe accuracy of TVUS and MRI in evaluating myometrial infiltration, cervical invasion and tumor volume were comparable. A tumor volume ≥2 ml showed a positive correlation with worse histological prognostic factors, such as high tumor grade, diffuse lymphvascular space involvement (LVSI) and deep myometrial invasion (p < 0.05).ConclusionTVUS should be used as first‐line imaging modality, being more available, cost‐effective, and more acceptable by patients. A careful local staging of endometrial cancer patients before surgery is fundamental in order to improve tailored treatment and minimize costs.

Changes in left ventricular function induced by carboplatin combined with paclitaxel in patients with ovarian cancer identified using three‐dimensional spot tracking imaging technology

AbstractObjectiveTo investigate the clinical value of three‐dimensional speckle tracking imaging (3D‐STI) in evaluating left ventricular (LV) systolic function in patients with ovarian cancer (OC) treated with paclitaxel and carboplatin.MethodWe studied 30 patients with OC treated with paclitaxel combined with carboplatin chemotherapy. Two‐dimensional echocardiography and 3D‐STI were performed in the patients before they underwent 2‐ and 6‐cycle chemotherapies, and in 30 normal control subjects. Were measured LV end‐diastolic volume (EDV), end‐systolic volume (ESV), three‐dimensional LV ejection fraction (3D‐LVEF), stroke volume (SV), spherical index (SPI), LV end‐diastolic mass (LV EDmass), LV end‐systolic mass (LV ESmass), LV global longitudinal strain (GLS), global circumferential strain (GCS), global radial strain (GRS), global area strain (GAS) and cardiac troponin T(cTnT). At the end of chemotherapy, magnetic resonance imaging (MRI) was also performed.ResultThe 3D conventional strain values (3D‐LVEF, SV, LV EDV) after the 2‐ and 6‐cycle chemotherapy were lower than before chemotherapy. LV Edmass, LV ESmass and cTnT were higher while LV GLS, GCS, GRS, GAS were lower after 2‐ and after 6‐cycle chemotherapy than before chemotherapy. There was no significant difference in ESV and EDV between the 3D‐STI and MRI parameters. GAS showed a significant negative correlation with cTnT. MRI and 3D‐STI variables were significantly correlated, and the receiver operating characteristic curves showed the greater area under the curve for GAS after 2‐ and after 6‐cycle chemotherapy. After 2‐cycle chemotherapy, the highest specificity for GAS was 93.3%, and the highest sensitivity for GLS was 70.0%. After 6‐cycle chemotherapy, the highest specificity for GAS was 96.7%, and the highest sensitivity for GLS was 96.7%.ConclusionThe LV systolic function decreased in OC patients treated with paclitaxel and carboplatin, showing that 3D‐STI may detect early LV systolic dysfunction.

Publisher

Wiley

ISSN

0091-2751