Journal
Synthesis and biological study of the phomopsolide and phomopsolidone natural products
A review of the discovery, synthesis and medicinal chemistry of the phomopsolide and phomopsolidone classes of regioisomeric polyketides is presented.
Visual detection of HPV16 using a photoactivatable CRISPR–Cas12 system
HPV screening is critical for the diagnosis of cervical cancer. This study combines photoactivated CRISPR-Cas12a with a tube-in-tube structure and RPA for rapid HPV16 detection, using blue UV light at 302 nm for portable, on-site diagnostics.
Intracellular delivery of therapeutic proteins through N-terminal site-specific modification
Adopting orthogonal dual-labeling strategies, a cell-permeable RNase A prodrug was designed for ROS-responsive targeted cancer therapy.
Amplified AND logic platform for cell identification
Herein, we developed an amplified AND logic platform (AALP) on a cell membrane, which integrated two DNA aptamers for cell recognition and a localized catalytic hairpin assembly (LCHA) for signal amplification.
Combining viscosity-restricted intramolecular motion and mitochondrial targeting leads to selective tumor visualization
We report a novel fluorescent molecular conjugate,V-M1,enabling an accurate visualization of tumor tissues.
A tumor-targeted near-infrared fluorescent probe for HNO and its application to the real-time monitoring of HNO release in vivo
A tumor-targeted near-infrared fluorescent probe has been developed for monitoring the intratumoral release of HNO from its donors in vivo.
Stable high-oxidation-state complex in situ Mn(v)–Mn(iii) transition to achieve highly efficient cervical cancer therapy
Stable high-oxidation-state Mn complexes were employed for efficient cancer therapy through an in situ Mn(v)–Mn(iii) transition to disrupt the redox balance.
Ligand-free 99m Tc-polyurea dendrimer complexes: nanoradiotheranostics targeting ovarian cancer
Folate-targeted polyurea dendrimers are radio-adhesive nanoparticles that enable straightforward radiolabelling with Technetium-99m by a surficial tridentate amine assisted-chelation.
Biotinylated photoactive Pt(iv) anticancer complexes
Novel biotinylated diazido-Pt(iv) complexes exhibit high visible light photocytotoxicity while being stable in the dark.
CRISPR-Cas12a-enhanced mass spectrometric DNA nanomachine for HPV-16 detection in human serum
Amplified by CRISPR-Cas12a and DNA nanomachines, the sensitive detection of HPV-16 in human serum was performed using mass spectrometry.
Photochemistry and in vitro anticancer activity of Pt(iv)Re(i) conjugates
The photoactivation of two Pt(iv)Re(i) conjugates was investigated and leveraged for eradicating ovarian cancer cells.
Fatty acid-like Pt(iv) prodrugs overcome cisplatin resistance in ovarian cancer by harnessing CD36
The fatty acid-like Pt(iv) prodrugs act as a “Trojan horse” to exploit upregulated CD36 receptors to facilitate their entry to ovarian cancer cells.
Dual-targeting RNA nanoparticles for efficient delivery of polymeric siRNA to cancer cells
A new dual-targeting polymeric siRNA nanoparticle (Dual-PSNP) was developed. The Dual-PSNP showed significantly enhanced cancer-specific intracellular delivery, gene regulation efficacy, and apoptosis-mediated cytotoxicity through additive receptor-mediated interactions of the two ligands.
Imaging of ovarian cancers using enzyme activatable probes with second near-infrared window emission
A β-galactosidase (β-Gal) activatable NIR-II fluorescent probe for visualizing ovarian cancers.
Royal Society of Chemistry (RSC)
1359-7345
