Synthesis and biological study of the phomopsolide and phomopsolidone natural products
<p>A review of the discovery, synthesis and medicinal chemistry of the phomopsolide and phomopsolidone classes of regioisomeric polyketides is presented.</p>
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Chemical CommunicationsInstitutions
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Targeted modification of the apramycin 2-deoxystreptamine ring to block aminoglycoside modifying enzyme-based inactivation and enhance potency against multidrug-resistant Gram-negative pathogensApramycin scaffold exploration using novel glycochemistry and SAR studies to enhance activity against Acinetobacter baumannii and other multidrug-resistant Gram-negative pathogensFusidic acid derivatization to enhance entry into Gram-negative pathogensNational Science Foundation Grant CHE-1565788Fusidic acid derivatization to enhance entry into Gram-negative pathogensTargeted modification of the apramycin 2-deoxystreptamine ring to block aminoglycoside modifying enzyme-based inactivation and enhance potency against multidrug-resistant Gram-negative pathogensApramycin scaffold exploration using novel glycochemistry and SAR studies to enhance activity against Acinetobacter baumannii and other multidrug-resistant Gram-negative pathogens