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Study dataset

Ongoing genome doubling shapes evolvability and immunity in ovarian cancer

Single-cell WGS of 70 untreated HGSOC samples from 41 patients: 30,260 genomes.

Listed Apr 24, 2026

  • Single-cell
  • Genomic
  • Ovarian

Overview

The Dataset

Using single-cell whole-genome sequencing, the authors analysed 70 HGSOC samples from 41 patients, generating 30,260 tumour genomes. This is one of the largest single-cell genomic datasets ever assembled for any cancer type.

The samples were treatment-naïve (untreated at time of diagnosis), and the multimodal approach also included site-matched immunofluorescent staining for markers of micronuclei and DNA sensing.

Publications