Overview
The dataset identifies associations between tumor genomic alterations and patterns of metastatic dissemination across 50 tumor types; showing that chromosomal instability is strongly correlated with metastatic burden in some tumor types, like prostate and lung adenocarcinomas and HR+/HER2+ breast ductal carcinoma, but not in others, such as colorectal MSS, pancreatic adenocarcinoma and high-grade serous ovarian cancer. The study also identifies somatic alterations associated with increased metastatic burden and routes of metastatic spread. Our data offers a resource for the investigation of the biologic basis for metastatic spread and highlights the role of chromosomal instability in cancer progression.
The cohort spans 50 tumor types, making it the largest integrated pan-cancer metastatic genomics dataset assembled from a single institution at the time of publication.
Genomic Platform
All samples were profiled using the MSK-IMPACT targeted sequencing panel, which identifies somatic mutations, rearrangements, and copy-number alterations in 341–468 cancer genes, as well as tumor mutational burden (TMB), chromosomal instability (CIN), and microsatellite instability (MSI).
Clinical Data
Metastatic events were extracted from the electronic health records (EHR) and mapped to a reference set of 21 anatomic locations, enabling systematic analysis of organ-specific patterns of metastatic spread (organotropism) across cancer types.