Overview
The Cohort — 11 Patients
Eleven treatment-naïve patients underwent debulking surgery with curative intent to remove tumors found in the endometrium or ovary. All tumors were primary tumors except for Patient 6 (an endometrial cancer that had metastasized to the ovary) and Patient 11 (a gastro-intestinal stromal tumor that had metastasized to the ovary).
Patient ages ranged from 49–76 years; race/ethnicity included African American, Caucasian, and Asian donors; BMI ranged from 22–55.
Scale
After quality control and doublet removal, the authors obtained 75,523 cells profiled by scRNA-seq and 74,621 cells profiled by scATAC-seq — over 150,000 single cells total across the 11 patients.
Public Data
The full dataset (>170,000 single cells across scRNA-seq and scATAC-seq) is publicly available and was deposited for community reuse — making it one of the most valuable open-access gyne cancer single-cell resources available, directly compatible with platforms like CELLxGENE Discover.
Notes
Rare matched scRNA-seq/scATAC-seq modality — highly valuable for regulatory genomics. Also accessible via CELLxGENE Discover.