Tracking clonal evolution during treatment in ovarian cancer using cell-free DNA

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Marc J. Williams; Michelle Wu; Nancy Varice; Duaa H. Al-Rawi; Hannah J. Lees; Jake June-Koo Lee; Matthew A. Myers; Matthew Zatzman; Nicole Rusk; Emily Ali; Ronak H. Shah; Michael F. Berger; Yulia Lakhman; Andrew McPherson; Dmitriy Zamarin; Brian Loomis; Britta Weigelt; Claire F. Friedman; Sohrab P. Shah

doi:10.1038/s41586-025-09580-0

Tracking clonal evolution during treatment in ovarian cancer using cell-free DNA

Marc J. Williams & Sohrab P. Shah et al. · 2025-10-01

Emergence of drug resistance is the main cause of therapeutic failure in patients with high-grade serous ovarian cancer (HGSOC)

Funding

NCI NIH HHS

P30 CA008748

NCI NIH HHS

U24 CA264028

NCI NIH HHS

P50 CA247749

NCI NIH HHS

K99 CA256508

NCI NIH HHS

R01 CA281928

NCI NIH HHS

R01 CA269382

Tracking clonal evolution during treatment in ovarian cancer using cell-free DNA

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