Ovarian cancer mutational processes drive site-specific immune evasion

Ignacio Vázquez-García & Dmitriy Zamarin et al. · 2022-12-14

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15Influential
High-grade serous ovarian cancer is a genomically complex malignancy. Here the authors integrate whole-genome sequencing, single-cell RNA sequencing, digital histopathology and multiplexed immunofluorescence across 160 tumour sites from 42 patients, revealing that mutational processes shape site-specific immune evasion.
Links
DOIPubMed
Journal
Nature
TL;DR

Multi-modal analysis of genomically unstable ovarian tumours characterizes the contribution of anatomical sites and mutational processes to evolutionary phenotypic divergence and immune resistance mechanisms and provides a multi-omic cellular phenotype data substrate from which to develop and interpret future personalized immunotherapeutic approaches and early detection research.

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Institutions
Memorial Sloan Kettering Cancer CenterNew York Medical CollegeIcahn School Of Medicine At Mount Sinai
Authors
Ignacio Vázquez-García, Florian Uhlitz, Michelle Wu, Kevin M. Boehm, Tyler Funnell, Druv M. Patel, Nicole Rusk, Marc J. Williams, Matthew Lennon, Ritika Kundra, Fresia Pareja, Ying L. Liu, Andrea Schietinger, Travis J. Hollmann, Britta Weigelt, Sohrab P. Shah, Dmitriy Zamarin
Funding
Cancer Research UK Grant 21143Center for Integrated Cellular AnalysisTowards a spatial view of Ras signaling and immune cell function in NF-1 mutant glioblastomaPathologyMSK SPORE in Genomic Instability in Breast CancerSingle cell quantification of genomic instability in cancer as a determinant of therapeutic responseMSK SPORE in Genomic Instability in Breast CancerWeill Cornell/Rockefeller/Sloan Kettering MST ProgramMultimodal computational models to stratify ovarian cancer patientsMSK Paul Calabresi Career Development Award for Clinical Oncology