Investigator
Memorial Sloan Kettering Cancer Center
Ovarian cancer mutational processes drive site-specific immune evasion
High-grade serous ovarian cancer is a genomically complex malignancy. Here the authors integrate whole-genome sequencing, single-cell RNA sequencing, digital histopathology and multiplexed immunofluorescence across 160 tumour sites from 42 patients, revealing that mutational processes shape site-specific immune evasion.
Multimodal data integration using machine learning improves risk stratification of high-grade serous ovarian cancer
Integration of genomic, histopathology, radiomics and clinical data using machine learning improves risk stratification for 444 patients with high-grade serous ovarian cancer.
