Menopausal hormone therapy use and risk of ovarian cancer by race: the ovarian cancer in women of African ancestry consortium

Jessica L. Petrick & Joellen M. Schildkraut et al. · 2023-10-21

Most studies examining post-menopausal menopausal hormone therapy (MHT) use and ovarian cancer risk have focused on White women and few have included Black women. We evaluated MHT use and ovarian cancer risk in Black (n = 800 cases, 1783 controls) and White women (n = 2710 cases, 8556 controls), using data from the Ovarian Cancer in Women of African Ancestry consortium. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association of MHT use with ovarian cancer risk, examining histotype, MHT type and duration of use. Long-term MHT use, ≥10 years, was associated with an increased ovarian cancer risk for White women (OR = 1.38, 95%CI: 1.22-1.57) and the association was consistent for Black women (OR = 1.20, 95%CI: 0.81-1.78, p The association between long-term MHT use and ovarian cancer risk was consistent for Black and White women.
Links
DOIPubMed
Journal
British Journal of Cancer
Institutions
Boston UniversityMoffitt Cancer CenterRutgers Cancer InstituteUniversity Of UtahOffice Of Minority HealthState University Of New YorkEmory University
Authors
Jessica L. Petrick, Lauren C. Peres, Elisa V. Bandera, Mollie E. Barnard, Traci N. Bethea, Heather M. Ochs-Balcom, Joellen M. Schildkraut
Funding
Hormone Therapy and Risk of Ovarian CancerAn assessment of whether aspirin and/or vitamin D improves breast cancer outcomes in Black women and the modifying effect of genetic variantsA Follow-up Study for Causes of Cancer in Black WomenCancer Research Training and Education CoordinationThe Molecular Epidemiology Of Ovarian CancerInterpretable Machine Learning to Identify Alzheimer's Disease Therapeutic TargetsUnderstanding Population Differences in Cancer: The MEC StudySURVEILLANCE EPIDEMIOLOGY AND END RESULTSExploring factors related to racial disparities in ovarian cancer incidence and survival: the OCWAA consortiumOvarian Cancer and Gonadotropin SignalingResearch CoreSURVEILLANCE EPIDEMIOLOGY & END RESULTS PROGRAMA Follow-up Study for Causes of Cancer in Black WomenA Follow-up Study for Causes of Illness in Black WomenEpidemiology of Ovarian Cancer in African-American WomenThe Progesterone Receptor Gene and Ovarian Cancer RiskThe Role of Inflammation in the Racial Disparities in Ovarian Cancer SurvivalExploring factors related to racial disparities in ovarian cancer incidence and survival: the OCWAA consortiumU.S. Department of Health & Human Services | NIH | National Cancer Institute FundingEpidemiology of Ovarian Cancer in African-American Women

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P01 CA017054

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K01 CA212056

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U01 CA164974

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P30 CA014089

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R01 CA076016

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R01 AG061132

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U01 CA164973

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N01 CN025403

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R01 CA207260

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R03 CA115195

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P60 MD003424

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N01 PC067010

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UM1 CA164974

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R01 CA058420

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R01 CA142081

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R03 CA113148

NCI NIH HHS

K99 CA218681

U.S. Department of Health & Human Services | NIH | National Cancer Institute

R01CA207260