Clinical and biological characteristics associated with loss-of-heterozygosity in endometrial cancer
Genomic instability has been identified in a subgroup of endometrial cancers (ECs) that are predominantly We conducted a retrospective analysis of EC patients from France and Singapore. All patients underwent comprehensive molecular profiling using the tumor based FoundationOne CDX panel. The degree of LOH was correlated with molecular and clinicopathologic findings. LOH-high, intermediate and low were defined as ≥14%, 4%-14%, and <4%, respectively. One hundred twelve patients were identified, including 66% Asian and 34% Caucasian. Fifty nine percent had International Federation of Gynecology and Obstetrics III/IV diseases, 34% low-grade endometrioid, 19% high-grade endometrioid, and 15% serous. The 63% and 50% of tumors expressed estrogen receptor (ER) and progesterone receptor (PR). One percent had a In this large multiethnic cohort, 17% of EC exhibited high LOH and correlated with hormone-receptor-negative tumors and poorer survival rates. LOH may serve as a tool for identifying EC cases with high genomic instability that could potentially benefit from PARP inhibitors.
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Funding
National University of Singapore President's Graduate Fellowship FundingNational Medical Research Council Singapore Clinician Scientist Award Senior Investigator Grant Grant CSASI21jun-003Pangestu Family Foundation Gynaecological Cancer Research Fund FundingShining Tower Foundation Medicine Grant FundingNational University of Singapore President’s Graduate Fellowship Funding