Harnessing small extracellular vesicles for pro-oxidant delivery: novel approach for drug-sensitive and resistant cancer therapy

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doi:10.1016/j.jconrel.2023.11.031

Harnessing small extracellular vesicles for pro-oxidant delivery: novel approach for drug-sensitive and resistant cancer therapy

Changsun Kang & Dongin Kim et al. · 2023-11-25

14Citations

Links

DOI PubMed

Journal

Journal of Controlled Release

TL;DR

GSH-depleting benzoyloxy dibenzyl carbonate-encapsulated sEVs (BsEVs) are developed, which overcome the efflux system to exert highly potent anticancer activity against human MDR ovarian cancer cells by depleting GSH to induce oxidative stress and, in turn, apoptotic cell death in both OVCAR-8/MDR and OVCar-8 cancer cells.

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Authors

Changsun Kang, Xiaoyu Ren, Dongwon Lee, Rajagopal Ramesh, Susan Nimmo, Yang Yang-Hartwich, Dongin Kim

Funding

Exosomes as carriers of cancer therapeutics Engineered Nanoformulation for Immune-modulation in Cancer Clinical Protocol and Data Management Mentoring Translational Cancer Research in Oklahoma An improved IL-24 gene-based therapeutic for cancer A New Ovarian Cancer Mouse Model Based on Nanoparticle Gene Delivery Uncovering the Mechanisms of Metastasis in Fallopian Tube-Originated Ovarian Cancer

NCI NIH HHS

R01 CA254192

NCI NIH HHS

R01 CA282735

NCI NIH HHS

P30 CA225520

NIGMS NIH HHS

P20 GM103639

NCI NIH HHS

R01 CA233201

NCI NIH HHS

R03 CA216127

NCI NIH HHS

R01 CA269779