Cervical versus endometrial injection for sentinel lymph node detection in endometrial cancer: a randomized clinical trial
To evaluate the relationship between pelvic/para-aortic sentinel lymph node status and two different injection sites of 99m-technetium ( This was a randomized controlled trial involving 81 patients with endometrial cancer. In the cervical group (n=40), injections of The rate of detection of at least one sentinel lymph node, sensitivity, and the negative predictive value was 80%, 66.6%, 96.6% for the cervical group and 85%, 66.6%, 96.9% for the endometrial group, respectively. False-negative sentinel lymph nodes were detected in one patient from each group . There was no significant difference between the groups in terms of total sentinel lymph node count, sentinel pelvic lymph node count, and pelvic bilaterality, but the para-aortic sentinel lymph node count was significantly higher in the endometrial group (p<0.001). Ultra-staging examination of the pelvic sentinel lymph nodes revealed isolated tumor cells in one patient from each group. Transcervical endometrial tracer injection in endometrial cancer revealed similar pelvic but significantly higher para-aortic sentinel lymph node detection.