Low-Dose Bisphenol A in a Rat Model of Endometrial Cancer: A CLARITY-BPA Study
Bisphenol A (BPA) is known to be biologically active in experimental models even at low levels of exposure. However, its impact on endometrial cancer remains unclear. This study aimed to investigate whether lifelong exposure to different doses of BPA induced uterine abnormalities and molecular changes in a rat model. Sprague-Dawley rats were exposed to 5 doses of BPA [0, 25, 250, 2,500, or Based on the analysis of the combined effects of all testing outcomes (including immunohistological, morphological, and estrous cycle data) in a semiblinded fashion, using statistical models, Lifelong exposure of rats to low-dose BPA at 25 and