Rapid detection of HPV16/18 based on a CRISPR-Cas13a/Cas12a dual-channel system

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Shuaiyin Chen

doi:10.1039/d2ay01536f

Rapid detection of HPV16/18 based on a CRISPR-Cas13a/Cas12a dual-channel system

Shuaiyin Chen · 2022-12-15

19Citations

1Influential

Orthogonal cleavage of DNA and RNA reporters by target-activated Cas12a/Cas13a induces two-colored fluorescence emission (JOE-FAM), which can be detected using a standard fluorometer or observed by a dual-channel visualization detection platform.

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Analytical Methods

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A highly sensitive and specific nucleic acid assay based on a CRISPR-Cas13a/Cas12a dual-channel system combined with multiplex RAA for rapid detection and typing of HPV16/18, which provides a new idea for cervical cancer screening.

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Rapid detection of HPV16/18 based on a CRISPR-Cas13a/Cas12a dual-channel system

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