OTUD6A in tubular epithelial cells mediates angiotensin II-induced kidney injury by targeting STAT3

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Shengbin Huang; Guang Liang

doi:10.1152/ajpcell.00394.2023

OTUD6A in tubular epithelial cells mediates angiotensin II-induced kidney injury by targeting STAT3

Shengbin Huang & Guang Liang · 2023-12-18

10Citations

Ovarian tumor domain-containing protein 6 A (OTUD6A) knockout mice are protected against angiotensin II-induced kidney dysfunction and fibrosis. OTUD6A promotes pathological kidney remodeling and dysfunction by deubiquitinating signal transducer and activator of transcription 3 (STAT3). OTUD6A binds to and removes K63-linked-ubiquitin chains of STAT3 to promote its phosphorylation and activation, and subsequently enhances kidney fibrosis.

Links

DOI PubMed

Journal

American Journal of Physiology-Cell Physiology

TL;DR

Investigating the role and underlying mechanism of OTUD6A during kidney fibrosis in HKD revealed higher OTUD6A expression in kidney tissues of nephropathy patients and mice with chronic Ang II administration than that from the control ones, indicating OTUD6A as a potential therapeutic target for HKD.

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Institutions

Wenzhou Medical University Hangzhou Medical College

Authors

Shengbin Huang, Guang Liang

Funding