Investigator
deputy director · Wenzhou Medical University, School of Stomatology
OTUD6A in tubular epithelial cells mediates angiotensin II-induced kidney injury by targeting STAT3
Ovarian tumor domain-containing protein 6 A (OTUD6A) knockout mice are protected against angiotensin II-induced kidney dysfunction and fibrosis. OTUD6A promotes pathological kidney remodeling and dysfunction by deubiquitinating signal transducer and activator of transcription 3 (STAT3). OTUD6A binds to and removes K63-linked-ubiquitin chains of STAT3 to promote its phosphorylation and activation, and subsequently enhances kidney fibrosis.
deputy director
Wenzhou Medical University · School of Stomatology
clinical doctor of Stomatology
Sichuan University · School of Stomatology