Tuning Nanoparticle Interactions with Ovarian Cancer through Layer-by-Layer Modification of Surface Chemistry
Nanoparticle surface chemistry is a fundamental engineering parameter that governs tumor-targeting activity. Electrostatic assembly generates controlled polyelectrolyte complexes through the process of adsorption and charge overcompensation utilizing synthetic polyions and natural biomacromolecules; it can yield films with distinctive hydration, charge, and presentation of functional groups. Here, we used electrostatic layer-by-layer (LbL) assembly to screen 10 different surface chemistries for their ability to preferentially target human ovarian cancer
Journal
ACS NanoAuthors
Funding
LbL Nanotechnologies for Synergistic Therapy of Advanced Ovarian CarcinomaLeadership, Planning and EvaluationIdentifying and targeting evolutionary trajectories in cancerInterdepartmental Biotechnology Training ProgramHHS | NIH | National Cancer Institute Grant P30-CA14051Ovarian Cancer Research Fund FundingAlfred P. Sloan Foundation FundingLbL Nanotechnologies for Synergistic Therapy of Advanced Ovarian CarcinomaCongressionally Directed Medical Research Programs Grant W81XWH-13-1-0151Thomas and Stacey Siebel Foundation FundingNational Science Foundation Grant DMR-0819762National Science Foundation Grant GFRP 1122374Koch Institute?s Marble Center for Cancer Nanomedicine Funding