Precision-Oriented Theophylline-Platinum(IV) Prodrugs: Eliciting Synthetic Lethality in BRCA1-Deficient Ovarian Cancer with Enhanced Efficacy and Reduced Toxicity In Vitro and In Vivo
Ovarian cancer (OC) is a lethal gynecologic malignancy with limited treatments. Platinum(II) drugs are commonly used but faced severe toxicities and resistance. This study developed theophylline-platinum(IV) prodrugs (
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Funding
Ministry of Science and Technology of the People's Republic of China Grant 21977080Ministry of Science and Technology of the People's Republic of China Grant 22377090Ministry of Science and Technology of the People's Republic of China Grant 82072752Ministry of Science and Technology of the People's Republic of China Grant 82271895