PPP2R1A mutations portend improved survival after cancer immunotherapy

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doi:10.1038/s41586-025-09203-8

PPP2R1A mutations portend improved survival after cancer immunotherapy

Yibo Dai & Amir A. Jazaeri et al. · 2025

Immune checkpoint blockade (ICB) therapy is effective against many cancers, although resistance remains a major issue and new strategies are needed to improve clinical outcomes

Links

DOI PubMed

Journal

Unknown Journal

Authors

Yibo Dai, Anne Knisely, Mitsutake Yano, Minghao Dang, Emily M. Hinchcliff, Sanghoon Lee, Annalyn Welp, Manoj Chelvanambi, Matthew Lastrapes, Heng Liu, Zhe Yuan, Chen Wang, Hao Nie, Stephanie Jean, Luis J. Montaner, Jiakai Hou, Ami Patel, Shrina Patel, Bryan Fellman, Ying Yuan, Baohua Sun, Renganayaki Krishna Pandurengan, Edwin Roger Parra Cuentas, Joseph Celestino, Yan Liu, Jinsong Liu, R. Tyler Hillman, Shannon N. Westin, Anil K. Sood, Pamela T. Soliman, Aaron Shafer, Larissa A. Meyer, David M. Gershenson, David Vining, Dhakshinamoorthy Ganeshan, Karen Lu, Jennifer A. Wargo, Weiyi Peng, Rugang Zhang, Linghua Wang, Amir A. Jazaeri

Funding

Training of Academic Gynecologic Oncologists Cancer Center Support Grant Signaling basis of senescence-associated secretory phenotype and its implications in epithelial ovarian cancer Health Services Career Development: Improving Medical Decisions in Ovarian Cancer Animal Shared Resource Synthetic lethality based combination approaches to ARID1A mutation in ovarian cancer General Clinical Research Center Metabolic basis of ARID1A-mutated ovarian cancer Project 2: Combination PARPi-BETi to Overcome PARPi Resistance Developmental Research Program NCI NIH HHS Grant L30 CA123720 Mechanistic basis and therapeutic strategies for ARID1A mutation in ovarian cancer NovaSeq6000 Regulation of tumor recurrence by stress activated neutrophils Tumor cell lineage diversity and composition in gastric cancer progression and therapy resistance Development of the MasSpec Pen Technology to Guide Surgical Decisions in the Care for Patients with Ovarian Cancer Center for Gastric Pre-Cancer Atlas of Multidimensional Evolution in 3D (GAME3D)