Neoadjuvant chemotherapy in patients with stage IVB uterine serous carcinoma: a Turkish multicentric study

MEHMET ÜNSAL & Taner Turan et al. · 2022-12-12

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The aim of this study was to evaluate the prognostic factors for and determine the effect of neoadjuvant chemotherapy (NACT) on oncologic outcome in stage IVB pure serous endometrial carcinoma patients who received taxane and platinum. Forty-two patients with 2009 International Federation of Gynecology and Obstetrics (FIGO) stage IVB uterine serous carcinoma were enrolled from six gynecologic oncology centers and a study group was created. The study group had a 2-year disease-free survival (DFS) of 32% and 2-year disease-specific survival (DSS) of 73%. On univariate analysis; lymphadenectomy (not performed vs. performed), paraaortic lymph node metastasis (positive vs. negative) and number of metastatic lymph node count (≤5 vs. >5) were found to have statistical significance for DFS (
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TL;DR

Performing lymphadenectomy, presence of paraaortic lymph node and adnexal metastasis, number of metastatic lymph nodes and type of cytoreductive surgery improved survival in advanced stage USC patients, but NACT did not have a statistical significance as a predictor for disease-specific survival (DSS) and disease-free survival (DFS).

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Institutions
Kutahya Saglik Bilimleri UniversitesiUniversity Of Health SciencesAnkara Bilkent City HospitalAnkara Medipol NiversitesiAnkara UniversitySalk Bilimleri NiversitesiMraniye Eitim Ve Aratrma HastanesiAnkara Etlik City HospitalBaheehir University
Authors
MEHMET ÜNSAL, Cigdem Kilic, CANER ÇAKIR, Fatih Kilic, BURAK ERSAK, Sema Karakaş, Nedim Tokgozoglu, Bulut Varli, OKAN OKTAR, Gunsu Kimyon Comert, Isa Aykut Ozdemir, Nurettin Boran, Tayfun Toptas, Isin Ureyen, Vakkas Korkmaz, Salih Taskin, Ozlem Moraloglu Tekin, Yaprak Ustun, Tolga Tasci, Firat Ortac, Taner Turan