Ultrastructural Pathology

Comparison of ultrastructural changes and the anticarcinogenic effects of thymol and carvacrol on ovarian cancer cells: which is more effective?

Ovarian cancer is the seventh most common cancer worldwide in women. Many anticancer drugs are currently used clinically have been isolated from plant species or are based on such substances. Thymol (5-methyl-2-isopropylphenol) and carvacrol are oxygenated aromatic compounds from the monoterpene group. They are the main constituents of thyme essential oil and show antiproliferative, antioxidant, and antiseptic properties. The aim of this study is to compare the antiproliferative and apoptotic effects of thymol and carvacrol on SKOV-3 ovarian cancer cell line. The cancer cells were treated with different concentrations of thymol and carvacrol (100, 200, 400, 600 µM) at 24 h and 48 h durations. The cell viability was investigated by MTT assay and analysis of apoptosis with annexin V assay was determined. The study show that thymol and carvacrol significantly induced apoptosis in all groups as dose and time-dependent (

Aggressive angiomyxoma: an ultrastructural study update of five cases

The aggressive angiomyxoma (AAM) is a rare mesenchymal tumor known for its locally aggressive behavior and high recurrence rate, predominantly affecting women. Through this analysis of five cases located in the vulva, scrotum, and perineum, the study employs histopathological, immunohistochemical, and ultrastructural techniques to elucidate the tumor's characteristics. Findings revealed confirmatory histopathological and immunohistochemical features. The ultrastructural study details the distinctive features of this entity showing characteristics compatible with myofibroblastic differentiation.