Molecular Biology of the Cell

Agent-based modeling predicts RAC1 is critical for ovarian cancer metastasis

Manipulation of Rac1 expression and agent-based modeling pinpoint rate-limiting step(s) in ovarian metastasis. More rapid adhesion and intravasation with Rac1 overexpression predict higher tumor cell numbers in a shorter period of time reaching distant sites. Tumor cell crowding along blood vessels reduced cell numbers.

Ovarian carcinoma immunoreactive antigen–like protein 2 (OCIAD2) is a novel complex III–specific assembly factor in mitochondria

Using a combination of techniques (mass spectrometry, BN–PAGE, immunodetection, and mitochondrial in vitro import assays), it is reported that a previously poorly described protein, OCIAD2, localizes to the inner mitochondrial membrane and participates in the formation of electron transport chain complexes.

Quantitative biophysical metrics for rapid evaluation of ovarian cancer metastatic potential

Peritoneal cancer characterized by localized dissemination can be hard to treat due to a poor understanding of cellular properties driving metastasis. Using natural fibrillar environments, we present high throughput and high content quantitative strategy to measure biophysical properties of cells in ovarian cancer models on the timescale of hours.