Isolda Romero-Canelon

Multiaction Pt(IV) Complexes: Cytotoxicity in Ovarian Cancer Cell Lines and Mechanistic Studies

Ovarian cancer has the worst case-to-fatality ratio of all gynecologic malignancies. The main reasons for the high mortality rate are relapse and the development of chemoresistance. In this paper, the cytotoxic activity of two new multiaction platinum(IV) derivatives of cisplatin and oxaliplatin in a panel of ovarian cancer cells is reported.

NMR studies of group 8 metallodrugs:187Os-enriched organo-osmium half-sandwich anticancer complex

Synthesis of this187Os-enriched organo-osmium azopyridine anticancer complex, has allowed determination of187Os NMR J-couplings to ligand1H and13C, and the187Os chemical shift. The complex was also characterised by X-ray crystallography and MS.