Radiotracer stereochemistry affects substrate affinity and kinetics for improved imaging of system xC- in tumors

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doi:10.7150/thno.63237

Radiotracer stereochemistry affects substrate affinity and kinetics for improved imaging of system x_C^- in tumors

Hannah E. Greenwood & Timothy H. Witney et al. · 2022-01-24

Amino acid utilization is perturbed in cancer cells, which rewire their metabolism to support cell survival and proliferation. This metabolic reprogramming can be exploited for diagnostic purposes through positron emission tomography imaging of fluorine-18 labeled amino acids. Despite its promise, little is known regarding transporter-recognition of non-natural amino acid stereoisomers or their utility for cancer imaging. We report here the synthesis and

Links

DOI PubMed

Journal

Theranostics

Authors

Hannah E. Greenwood, Richard Edwards, Norman Koglin, Mathias Berndt, Friedrich Baark, Jana Kim, George Firth, Eman Khalil, Andre Mueller, Timothy H. Witney

Funding

Cancer Research UK Grant C416/A23233 Wellcome Trust Grant WT203148/Z/16/Z Wellcome Trust Grant 107610 Wellcome Trust Grant 220221/Z/20/Z Wellcome Trust Grant 107610/Z/15/Z Wellcome Trust Grant 220221