Ligase 1 is a predictor of platinum resistance and its blockade is synthetically lethal in XRCC1 deficient epithelial ovarian cancers

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doi:10.7150/thno.51456

Ligase 1 is a predictor of platinum resistance and its blockade is synthetically lethal in XRCC1 deficient epithelial ovarian cancers

Reem Ali & Srinivasan Madhusudan et al. · 2021-07-25

Links

DOI PubMed

Journal

Theranostics

Authors

Reem Ali, Muslim Alabdullah, Mashael Algethami, Adel Alblihy, Islam Miligy, Ahmed Shoqafi, Katia A. Mesquita, Tarek Abdel-Fatah, Stephen YT Chan, Pei Wen Chiang, Nigel P Mongan, Emad A Rakha, Alan E Tomkinson, Srinivasan Madhusudan

Funding

NOVEL APPROACHES TO ALKALOID SYNTHESIS Early Career Cancer Clinical Investigator Award (ECIA)Roles of Lig3 and XRCC1 Genes in Genome Stability Core 1: Expression and Molecular Biology (EMB)Roles of DNA Ligase I in Mammalian DNA Metabolism Cellular Functions of Eukaryotic DNA Ligases

NIGMS NIH HHS

R01 GM027251

NCI NIH HHS

P30 CA118100

NIEHS NIH HHS

R01 ES012512

NCI NIH HHS

P01 CA092584

NIGMS NIH HHS

R01 GM057479

NIGMS NIH HHS

R01 GM047251