Targeting platinum-resistant ovarian cancer by disrupting histone and RAD51 lactylation

Chenggong Sun & Beihua Kong et al. · 2025-02-10

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TL;DR

The essential role of histone and RAD51 lactylation in HR repair and platinum resistance is demonstrated and a potential therapeutic strategy to overcome platinum resistance and improve prognosis in ovarian cancer is identified.

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Authors
Chenggong Sun, Xiao Li, Qiuli Teng, Xihan Liu, Li Song, Helgi B. Schiöth, Huan Wu, Xinyue Ma, Zhaoyang Zhang, Changjian Qi, Haocheng Zhang, Kun Song, Qing Zhang, Beihua Kong